Medical science has been one of the most fascinating field in the industry. It has answered several questions regarding medical diseases and most importantly discovered several treatments for the many physical diseases of human. Clodronate liposome for example, are one of those remarkable discoveries which could play a great role in medicine.
Apart from cardiovascular and metabolic diseases, autoimmune diseases and cancer are among the common medical condition of people through out the world. What's worse is that both diseases remains to be incurable as all present therapies focuses on how to slow down the progression or worsening of the disease.
Through phagocytosis macrophage will be able to defend the body. Phagocytosis means the ingestion of bacteria and other foreign cell in the body by the phagocytes. In addition to that, it also activates to major lymphocytes the t lymphocytes and the b ones. In short, macrophage through phagocytosis activates the immune system of both human and animals.
In normal circumstances, this process makes the body cope up with simple diseases such as colds or cough, thus the term healthy immune system. However, a damage to the immune system could make it passive or overly active. An overly active immune system will result to autoimmune diseases, wherein your own immune cells are attacking your own cells causing several medical disorders.
Clodronate or also known as clodronic acid or clodronate disodium is a bisphosphonate that depletes macrophage hence reducing phagocytosis and suppresses the immune system. Liposomes on the other hand are artificially made lipid vesicles that are mostly used to encapsulate or carry strong hydrophilic substance in aqueous solution, for example clodronate.
During normal circumstances, such process is not harmful at all. Instead, it actually protects the body from infestation. But as mentioned, certain damages to the immune system could lead to serious autoimmune medical conditions. Transplant rejection is one of the effects of immune response. This time as the newly harvested organ is placed on the transplant patient, certain cells may trigger the immune system to attack the organ cells massively thus resulting to rejection.
To be able to manage such conditions, medical experts have stumbled upon clodronate, accidentally. Such experimental medicine is a bisphosphonate that is said to effectively deplete macrophage. Though the artificial lipid and drug vehicle liposome, clodronate is transported into the body. As soon as the macrophage detect such active drug as "foreign" this will automatically engulf it through phagocytosis.
As soon as the active component is released inside the macrophage cell, it will cause apoptosis, or in other words, cell death. With the death of macrophage cells, this will suppress the immune system. This is why, such component has shown promising results towards reducing disease progression of patients with autoimmune disease as well as prevent transplant rejection.
In cancer, clodronate liposome is said to improve the chemotherapeutic or to be specific the anti tumor activity in anti cancer drugs. More so, in certain cancer research such component have effectively decreased or suppress certain cancer cells that makes anti tumor drugs more absorbed into the plasma.
Apart from cardiovascular and metabolic diseases, autoimmune diseases and cancer are among the common medical condition of people through out the world. What's worse is that both diseases remains to be incurable as all present therapies focuses on how to slow down the progression or worsening of the disease.
Through phagocytosis macrophage will be able to defend the body. Phagocytosis means the ingestion of bacteria and other foreign cell in the body by the phagocytes. In addition to that, it also activates to major lymphocytes the t lymphocytes and the b ones. In short, macrophage through phagocytosis activates the immune system of both human and animals.
In normal circumstances, this process makes the body cope up with simple diseases such as colds or cough, thus the term healthy immune system. However, a damage to the immune system could make it passive or overly active. An overly active immune system will result to autoimmune diseases, wherein your own immune cells are attacking your own cells causing several medical disorders.
Clodronate or also known as clodronic acid or clodronate disodium is a bisphosphonate that depletes macrophage hence reducing phagocytosis and suppresses the immune system. Liposomes on the other hand are artificially made lipid vesicles that are mostly used to encapsulate or carry strong hydrophilic substance in aqueous solution, for example clodronate.
During normal circumstances, such process is not harmful at all. Instead, it actually protects the body from infestation. But as mentioned, certain damages to the immune system could lead to serious autoimmune medical conditions. Transplant rejection is one of the effects of immune response. This time as the newly harvested organ is placed on the transplant patient, certain cells may trigger the immune system to attack the organ cells massively thus resulting to rejection.
To be able to manage such conditions, medical experts have stumbled upon clodronate, accidentally. Such experimental medicine is a bisphosphonate that is said to effectively deplete macrophage. Though the artificial lipid and drug vehicle liposome, clodronate is transported into the body. As soon as the macrophage detect such active drug as "foreign" this will automatically engulf it through phagocytosis.
As soon as the active component is released inside the macrophage cell, it will cause apoptosis, or in other words, cell death. With the death of macrophage cells, this will suppress the immune system. This is why, such component has shown promising results towards reducing disease progression of patients with autoimmune disease as well as prevent transplant rejection.
In cancer, clodronate liposome is said to improve the chemotherapeutic or to be specific the anti tumor activity in anti cancer drugs. More so, in certain cancer research such component have effectively decreased or suppress certain cancer cells that makes anti tumor drugs more absorbed into the plasma.
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